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Detection of prostate-specific antigen coupled to immunoglobulin M in prostate cancer patients.
- Source :
-
Cancer detection and prevention [Cancer Detect Prev] 2007; Vol. 31 (5), pp. 402-7. Date of Electronic Publication: 2007 Nov 26. - Publication Year :
- 2007
-
Abstract
- Background: Several reports indicate that the main biomarkers for liver and colorectal cancer circulating in the blood stream associate with immunoglobulin M (IgM) to form stable complexes that show increased diagnostic relevance compared to circulating free biomarkers.<br />Methods: To further investigate the association between cancer biomarkers and IgM, we assessed the presence of prostate-specific antigen (PSA) as IgM complexes in sera of patients with prostate cancer (PC) or benign prostatic hyperplasia (BPH) in comparison with PSA measurements.<br />Results: PSA-IgM levels were significantly elevated in 40% (20/50) and 12% (6/51) of PC and BPH patients, respectively, compared to 22% (11/50) and 29% (15/51) of PSA positive patients in the same groups. Detection of cancer markedly increased from 22 to 60% by co-determination of both markers (30/50 patients). Significantly elevated levels of PSA-IgM were found in 13 out of 30 patients affected by PC with a PSA value between 4 and 10 ng/mL and only in 4 out of 34 BPH patients in the same PSA range.<br />Conclusions: The results are the first evidence of the occurrence of PSA-IgM complexes in patients with prostate cancer. The gain achieved in cancer detection by using the combination of PSA and PSA-IgM suggests that PSA-IgM could be a complementary serological marker of prostate cancer.
- Subjects :
- Area Under Curve
Chromatography, Gel
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin M chemistry
Immunoglobulin M immunology
Male
Prostate-Specific Antigen chemistry
Prostate-Specific Antigen immunology
ROC Curve
Sensitivity and Specificity
Antigen-Antibody Complex blood
Biomarkers, Tumor blood
Immunoglobulin M blood
Prostate-Specific Antigen blood
Prostatic Hyperplasia blood
Prostatic Neoplasms blood
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1500
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer detection and prevention
- Publication Type :
- Academic Journal
- Accession number :
- 18035503
- Full Text :
- https://doi.org/10.1016/j.cdp.2007.10.005