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Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease.
- Source :
-
Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2009 Jan; Vol. 27 (1), pp. 82-7. Date of Electronic Publication: 2007 Nov 27. - Publication Year :
- 2009
-
Abstract
- This study aimed to compare plasma levels of total homocysteine (tHcy) in different arterial events as well as to investigate an association between homocysteine levels and C677T polymorphism in Brazilian patients. A total of 145 subjects were enrolled in this study including 43 patients with coronary arterial disease (CAD), 21 with ischemic stroke (IS), 44 with peripheral arterial obstructive disease (PAOD) and 37 control subjects. A preliminary analysis showed significant difference for tHcy plasma levels between patients with CAD (P = 0.003) or PAOD (P = 0.03) compared to controls. However, after adjustment for sex, age, total cholesterol, LDL, diabetes, tabagism or C677T polymorphism, no significant differences were detected in tHcy levels among patients groups and controls. No significant correlation was demonstrated for C677T polymorphism and homocysteine levels. These results indicate that increased Hcy levels may not be considered an independent risk factor for atherothrombotic diseases in Brazilian patients.
- Subjects :
- Aged
Amino Acid Substitution
Arterial Occlusive Diseases epidemiology
Brain Ischemia epidemiology
Brazil epidemiology
Comorbidity
Coronary Disease epidemiology
Female
Humans
Hyperhomocysteinemia epidemiology
Male
Middle Aged
Mutation, Missense
Peripheral Vascular Diseases epidemiology
Risk Factors
Arterial Occlusive Diseases genetics
Brain Ischemia genetics
Coronary Disease genetics
Homocysteine blood
Hyperhomocysteinemia genetics
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Peripheral Vascular Diseases genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 0929-5305
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of thrombosis and thrombolysis
- Publication Type :
- Academic Journal
- Accession number :
- 18040753
- Full Text :
- https://doi.org/10.1007/s11239-007-0172-z