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Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2008 Aug; Vol. 43 (8), pp. 1742-8. Date of Electronic Publication: 2007 Oct 25. - Publication Year :
- 2008
-
Abstract
- Extended studies on the synthesis and pharmacological evaluation of (RS)-6-substituted-7 or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines are presented. The microwave-assisted organic synthesis has provided faster access to the target compounds with the advantage of selective obtaining the N-7' or N-9' regioisomers simplifying their isolation. To test the behaviour of the products (including the purine bases) on cellular systems, cytotoxic activity against the MCF-7 human breast cancer cell line was determined, and the three most active compounds were used to study the cell cycle distribution and apoptosis in the MCF-7 cell line.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Proliferation drug effects
Humans
Molecular Structure
Purines chemistry
Stereoisomerism
Structure-Activity Relationship
Antineoplastic Agents chemical synthesis
Benzoxepins chemistry
Breast Neoplasms pathology
Hydrogen chemistry
Microwaves
Purines chemical synthesis
Purines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0223-5234
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18069093
- Full Text :
- https://doi.org/10.1016/j.ejmech.2007.10.025