Back to Search
Start Over
Dectin-1 Fc targeting of aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Mar; Vol. 52 (3), pp. 1171-2. Date of Electronic Publication: 2007 Dec 17. - Publication Year :
- 2008
-
Abstract
- Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
- Subjects :
- Animals
Aspergillosis immunology
Aspergillosis microbiology
Aspergillosis mortality
Aspergillus fumigatus metabolism
Immunity, Innate
Immunoglobulin Fc Fragments chemistry
Immunoglobulin Fc Fragments immunology
Lectins, C-Type
Lung Diseases, Fungal immunology
Lung Diseases, Fungal microbiology
Lung Diseases, Fungal mortality
Macrophages, Alveolar immunology
Male
Membrane Proteins chemistry
Membrane Proteins immunology
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins chemistry
Nerve Tissue Proteins immunology
Aspergillosis therapy
Aspergillus fumigatus immunology
Immunoglobulin Fc Fragments therapeutic use
Lung Diseases, Fungal therapy
Membrane Proteins therapeutic use
Nerve Tissue Proteins therapeutic use
beta-Glucans immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 18086835
- Full Text :
- https://doi.org/10.1128/AAC.01274-07