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Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls.
- Source :
-
Psychiatry research [Psychiatry Res] 2008 Feb 28; Vol. 158 (1), pp. 83-6. Date of Electronic Publication: 2007 Dec 21. - Publication Year :
- 2008
-
Abstract
- The present study assessed 25 patients with unipolar major depression and 34 patients with schizophrenia along with 50 healthy, non-psychiatric controls for the presence of serum antinuclear (ANA), smooth muscle (SMA), anti-endothelial (AEA), anti-sarcolemma (ASA), thyroid gland (TGA) and parietal cell (PCA) antibodies. In the group of patients with major depression, the frequency of elevated ANA, TGA and PCA was significantly higher than in the control group. In addition, the group of patients with schizophrenia significantly more often showed increased levels of ANA and SMA than the control group of healthy volunteers. When the two psychiatric groups were compared, PCA serum titers in major depression and SMA values in schizophrenia were significantly more frequently elevated, whereas values of AEA and ASA showed no difference. These results point towards the existence of an unspecific (auto) immune disposition or reaction in at least a subgroup of patients with major depression and schizophrenia.
- Subjects :
- Depressive Disorder, Major epidemiology
Endothelium, Vascular immunology
Female
Humans
International Classification of Diseases
Male
Mass Screening methods
Middle Aged
Muscle, Smooth immunology
Parietal Cells, Gastric immunology
Prevalence
Sarcolemma immunology
Schizophrenia epidemiology
Severity of Illness Index
Thyroid Gland immunology
Antibodies, Antinuclear immunology
Autoantibodies blood
Autoantibodies immunology
Depressive Disorder, Major blood
Depressive Disorder, Major immunology
Schizophrenia blood
Schizophrenia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 158
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 18096244
- Full Text :
- https://doi.org/10.1016/j.psychres.2006.04.023