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Glycine cleavage system in astrocytes.
- Source :
-
Brain research [Brain Res] 1991 Dec 13; Vol. 567 (1), pp. 64-70. - Publication Year :
- 1991
-
Abstract
- The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest staining being noted in the hippocampus, the cerebellar cortex, the Bergmann glia in the cerebellum and the Muller cells in the retina. The weakest staining was seen in the brainstem and spinal cord. P-protein was found to be located in the mitochondria by an ultrastructual study.
- Subjects :
- Aminomethyltransferase
Animals
Astrocytes cytology
Astrocytes ultrastructure
Glutamine metabolism
Immunohistochemistry
Male
Microscopy, Immunoelectron
Organ Specificity
Rats
Rats, Inbred Strains
Astrocytes enzymology
Brain enzymology
Glycine metabolism
Hydroxymethyl and Formyl Transferases
Retina enzymology
Transferases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 567
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 1815830
- Full Text :
- https://doi.org/10.1016/0006-8993(91)91436-5