Is experimental endotoxaemia in humans suitable for simulating antibiotic pharmacokinetics in sepsis and septic shock? A pilot study using the model compound fosfomycin.

Authors :: Sauermann R
Mayer-Helm BX
Petsch M
Popovic M
Thallinger C
Joukhadar C
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2008 Mar; Vol. 31 (3), pp. 291-2. Date of Electronic Publication: 2007 Dec 21.
Publication Year :: 2008

Subjects :: Endotoxemia
Humans
Lipopolysaccharides administration & dosage
Male
Pilot Projects
Anti-Bacterial Agents pharmacokinetics
Anti-Bacterial Agents therapeutic use
Fosfomycin pharmacokinetics
Fosfomycin therapeutic use
Sepsis drug therapy
Shock, Septic drug therapy

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