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Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides.
- Source :
-
Arthritis and rheumatism [Arthritis Rheum] 2008 Jan; Vol. 58 (1), pp. 36-45. - Publication Year :
- 2008
-
Abstract
- Objective: The Sa autoantigen can be found in inflamed synovium of patients with rheumatoid arthritis (RA), and at least part of the humoral RA-specific anti-Sa response is directed against citrullinated vimentin. This study was undertaken to evaluate the sensitivity, specificity, and prognostic value of determination of levels of antibodies against modified citrullinated vimentin (anti-MCV) as compared with antibodies against cyclic citrullinated peptides (anti-CCP) in an inception cohort of patients with early RA.<br />Methods: Clinical data, radiographs, and measurements of levels of anti-MCV and anti-CCP antibodies were obtained in 273 patients with early RA at baseline, after 3 months, and after 1, 2, 3, and 5 years. Autoantibodies were also analyzed in 100 healthy controls.<br />Results: Of the 273 patients, 193 (70.7%) were anti-MCV positive and 158 (57.9%) were anti-CCP positive at the time of diagnosis, with nearly equal specificities (95% and 96%, respectively). Forty (14.7%) were anti-MCV positive only, and 5 (1.8%) were anti-CCP positive only. Anti-MCV-positive and anti-MCV-negative patients had similar disease activity at baseline, but presence of anti-MCV was predictive of subsequent high disease activity and continued radiographic progression. Changes in anti-MCV level showed stronger correlation with changes in clinical parameters than did changes in anti-CCP level. The subgroup of patients who were anti-MCV positive and anti-CCP negative showed a higher rate of radiographic destruction than did patients who were negative for both anti-MCV and anti-CCP.<br />Conclusion: These findings show that when patients with early RA are compared with healthy controls, analysis of anti-MCV yields greater sensitivity and unchanged specificity as compared with analysis of anti-CCP. Anti-MCV also appears to perform better than anti-CCP in identifying poor radiographic prognosis in patients with early RA.
- Subjects :
- Antibody Specificity
Arthritis, Rheumatoid diagnostic imaging
Citrulline immunology
Cohort Studies
Disease Progression
Enzyme-Linked Immunosorbent Assay methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Peptides, Cyclic immunology
Prognosis
Radiography
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid immunology
Autoantibodies blood
Biomarkers blood
Vimentin immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-3591
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 18163519
- Full Text :
- https://doi.org/10.1002/art.23188