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Rapid analysis of multiple pesticide residues in fruit-based baby food using programmed temperature vaporiser injection-low-pressure gas chromatography-high-resolution time-of-flight mass spectrometry.
- Source :
-
Journal of chromatography. A [J Chromatogr A] 2008 Apr 04; Vol. 1186 (1-2), pp. 281-94. Date of Electronic Publication: 2007 Dec 08. - Publication Year :
- 2008
-
Abstract
- A rapid method using programmed temperature vaporiser injection-low-pressure gas chromatography-high-resolution time-of-flight mass spectrometry (PTV-LP-GC-HR-TOF-MS) for the analysis of multiple pesticide residues in fruit-based baby food was developed. The fast and inexpensive buffered QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction method and "conventional" approach that employs ethyl acetate extraction followed by gel permeation chromatography (GPC) cleanup were employed for sample preparation. A PTV injector in solvent venting mode was used to reduce volume of acetonitrile and acetic acid (from the buffered QuEChERS extracts) that caused higher column bleed without their elimination. Otherwise, the time-to-digital converter would become saturated in HR-TOF-MS. For fast GC separation allowing analysis of 100 analytes within a 7 min runtime, both a high temperature programming rate and vacuum conditions in a megabore GC column were employed. The use of HR-TOF-MS allowed the unbiased identification and reliable quantification of target analytes through the application of a narrow mass window (0.02 Da) for extracting analyte ions and the availability of full spectral information even at very low levels. With only a few exceptions, the lowest calibration levels for the pesticides tested were <or=0.01 mg/kg for both sample preparation methods, which meets the EU maximum residue limit set for pesticide residues in cereal-based foods and baby foods (2003/13/EC).
- Subjects :
- Acetic Acid chemistry
Aminoimidazole Carboxamide analogs & derivatives
Aminoimidazole Carboxamide analysis
Buffers
Endosulfan analysis
Hydantoins analysis
Isomerism
Pesticide Residues isolation & purification
Pressure
Reproducibility of Results
Time Factors
Volatilization
Food Analysis methods
Fruit chemistry
Gas Chromatography-Mass Spectrometry methods
Pesticide Residues analysis
Temperature
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9673
- Volume :
- 1186
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. A
- Publication Type :
- Academic Journal
- Accession number :
- 18164024
- Full Text :
- https://doi.org/10.1016/j.chroma.2007.12.009