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Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph Consortium.
- Source :
-
International journal of cancer [Int J Cancer] 2008 May 01; Vol. 122 (9), pp. 2062-70. - Publication Year :
- 2008
-
Abstract
- Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m(-2) or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL subtypes. An excess was however observed for diffuse large B-cell lymphoma (pooled OR = 1.80, 95% CI 1.24-2.62), although not all study-specific ORs were raised. Among the overweight (BMI 25-29.9 kg m(-2)) and obese (BMI 30-39.9 kg m(-2)), associations were elevated in some studies and decreased in others, while no association was observed among the underweight (BMI < 18.5 kg m(-2)). There was little suggestion of increasing ORs for NHL or its subtypes with every 5 kg m(-2) rise in BMI above 18.5 kg m(-2). BMI components height and weight were also examined, and the tallest men, but not women, were at marginally increased risk (pooled OR = 1.19, 95% CI 1.06-1.34). In summary, whilst we conclude that there is no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined, the association between severe obesity and diffuse large B-cell lymphoma may warrant further investigation.<br /> ((c) 2007 Wiley-Liss, Inc.)
- Subjects :
- Adult
Aged
Body Height
Body Mass Index
Body Weight
Female
Humans
International Cooperation
Lymphoma, Large B-Cell, Diffuse epidemiology
Lymphoma, Non-Hodgkin etiology
Male
Middle Aged
Obesity epidemiology
Odds Ratio
Risk Assessment
Risk Factors
Lymphoma, Non-Hodgkin epidemiology
Obesity complications
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 122
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18167059
- Full Text :
- https://doi.org/10.1002/ijc.23344