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Low- and high-frequency electric cortical stimulation suppress the ferric chloride-induced seizures in rats.
- Source :
-
Neuroscience letters [Neurosci Lett] 2008 Jan 17; Vol. 430 (3), pp. 187-90. Date of Electronic Publication: 2007 Oct 30. - Publication Year :
- 2008
-
Abstract
- The clinic treatment of epilepsy with epileptic foci overlapped with eloquent cortex is not satisfactory. In this study we investigated the direct effects of low- and high-frequency electric cortical stimulation (ECS) on ferric chloride-induced seizures in the experimental rats. Results showed that spontaneous seizures were observed in all rats during the EEG recording after the intracortical injection of ferric chloride solution into left sensorimotor cortex. One-hertz or 100-Hz ECS with 0.3 ms duration and 0.1 mA amplitude square pulses in 1h on the cortical lesioned area significantly decreased the number of seizures compared with that of the non-stimulation control group. The mean duration time of seizures in 1-Hz or 100-Hz groups was apparently shorter than that in the control group. In brief, this study showed that both low- and high-frequency ECS suppressed the seizures induced by ferric chloride in rats, indicating their potential treatment effects on epilepsy in clinic.
- Subjects :
- Action Potentials drug effects
Action Potentials physiology
Animals
Cerebral Cortex drug effects
Chlorides
Convulsants
Electroencephalography
Epilepsy chemically induced
Ferric Compounds
Male
Motor Cortex drug effects
Motor Cortex physiopathology
Neural Inhibition drug effects
Neural Inhibition physiology
Rats
Rats, Sprague-Dawley
Somatosensory Cortex drug effects
Somatosensory Cortex physiopathology
Treatment Outcome
Cerebral Cortex physiopathology
Electric Stimulation Therapy methods
Epilepsy physiopathology
Epilepsy therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 430
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 18180108
- Full Text :
- https://doi.org/10.1016/j.neulet.2007.10.024