[The experimental study of peculiarities and mechanism of neuroprotective action of mexidol in hemorrhagic stroke].

Authors :: Kraĭneva VA
Source :: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2006; Vol. Suppl 17, pp. 71-6.
Publication Year :: 2006
Abstract: An efficacy of mexidol, a Russian drug of the new generation, used in 100 mkg during 7 days has been demonstrated in rats in the model of experimentally caused intracerebral posttraumatic hematoma (hemorrhagic stroke). The drug significantly reduced the number of neurological impairments (paresis, riding-arena movements) and increased the animal's survival rate. Mexidol improved learning and memory in rats with hemorrhagic stroke in the passive avoidance test and exerted influence on the locomotor activity in the open field test.

Subjects :: Animals
Brain Injuries complications
Cerebral Hemorrhage etiology
Cerebral Hemorrhage psychology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Learning drug effects
Locomotion drug effects
Male
Memory drug effects
Rats
Treatment Outcome
Cerebral Hemorrhage drug therapy
Picolines administration & dosage
Psychotropic Drugs administration & dosage

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