www.rnaworkbench.com: A new program for analyzing RNA interference.

Authors :: Vareková RS
Bradác I
Plchút M
Skrdla M
Wacenovsky M
Mahr H
Mayer G
Tanner H
Brugger H
Withalm J
Lederer P
Huber H
Gierlinger G
Graf R
Tafer H
Hofacker I
Schuster P
Polcík M
Source :: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2008 Apr; Vol. 90 (1), pp. 89-94. Date of Electronic Publication: 2008 Jan 22.
Publication Year :: 2008
Abstract: RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.