Occupation and lymphoid malignancies: results from a French case-control study.

Authors :: Orsi L
Troussard X
Monnereau A
Berthou C
Fenaux P
Marit G
Soubeyran P
Huguet F
Milpied N
Leporrier M
Hemon D
Clavel J
Source :: Journal of occupational and environmental medicine [J Occup Environ Med] 2007 Dec; Vol. 49 (12), pp. 1339-50.
Publication Year :: 2007
Abstract: Objectives: Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM).<br />Methods: We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews.<br />Results: Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association.<br />Conclusions: The results support the hypothesis that farming plays a role in most types of LM.