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Combining experiment and simulation in protein folding: closing the gap for small model systems.
- Source :
-
Current opinion in structural biology [Curr Opin Struct Biol] 2008 Feb; Vol. 18 (1), pp. 4-9. Date of Electronic Publication: 2008 Feb 01. - Publication Year :
- 2008
-
Abstract
- All-atom molecular dynamics (MD) simulations on increasingly powerful computers have been combined with experiments to characterize protein folding in detail over wider time ranges. The folding of small ultrafast folding proteins is being simulated on micros timescales, leading to improved structural predictions and folding rates. To what extent is 'closing the gap' between simulation and experiment for such systems providing insights into general mechanisms of protein folding?
Details
- Language :
- English
- ISSN :
- 0959-440X
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current opinion in structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 18242977
- Full Text :
- https://doi.org/10.1016/j.sbi.2007.11.007