Back to Search
Start Over
Immunity studies in calves vaccinated with a multivalent live respiratory vaccine composed of I.B.R., parainfluenza 3 and bovine adenovirus type 3.
Immunity studies in calves vaccinated with a multivalent live respiratory vaccine composed of I.B.R., parainfluenza 3 and bovine adenovirus type 3.
- Source :
-
Developments in biological standardization [Dev Biol Stand] 1976; Vol. 33, pp. 379-83. - Publication Year :
- 1976
-
Abstract
- The persistence of systemic and local antibodies was studied after two intranasal administrations of the vaccine, six weeks apart. Systemic antibodies to I.B.R. and adenovirus 3 evoked by the vaccine were still present 21 weeks following the second dose of the vaccine. Inconslusive results were obtained regarding the persistence of systemic and local PI-3 antibodies because of an intercurrent natureal PI-3 infection occurring during the observation period. Local antibodies to adenovirus type 3 were found in a high percentage of vaccinated animals 21 weeks after the second dose of the vaccine, whereas local antibodies to I.B.R. remained detectable in 50% of the animals eight weeks after thesecond dose. The results of a challenge study 21 weeks after revaccination show that the presence of local and systemic antibodies prevent the multiplication of PI-3 and BAV-3 in the upper respiratory tract. Protection against I.B.R. was achieved in the absence of detectable local antibodies.
- Subjects :
- Administration, Intranasal
Animals
Antibodies, Viral analysis
Immunity
Mucus immunology
Nose
Paramyxoviridae Infections prevention & control
Paramyxoviridae Infections veterinary
Adenoviridae immunology
Cattle immunology
Herpesvirus 1, Bovine immunology
Parainfluenza Virus 3, Human immunology
Respirovirus immunology
Viral Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0301-5149
- Volume :
- 33
- Database :
- MEDLINE
- Journal :
- Developments in biological standardization
- Publication Type :
- Academic Journal
- Accession number :
- 182597