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Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors.
- Source :
-
Neuroscience letters [Neurosci Lett] 2008 Mar 21; Vol. 434 (1), pp. 18-22. Date of Electronic Publication: 2008 Jan 16. - Publication Year :
- 2008
-
Abstract
- Repeated exposure to nicotine induces adaptive changes in the central nervous system including the mesolimbic dopamine (DA) projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc). These modifications can modulate nicotine reward and reinforcement, but also anxiety and depression-related behaviors. The development of addiction-related phenotypes is known to be modulated by regulation of glutamate receptors, as well as activation of transcription factors including cAMP response element-binding protein (CREB), in the NAc. We investigated the effects of nicotine pre-exposure on nicotine preference and levels of GluR1/2 and CREB in the mesolimbic system in male mice C57BL/6J and BALB/c inbred mice. We also evaluated locomotor activity, anxiety-like and depression-like behaviors known to be affected by nicotine. There were few behavioral changes in mice subjected to chronic nicotine exposure, but there was a marked regulation of GluR2 in the mesolimbic system. Both treated and non-treated animals showed a significant preference for nicotine when facing a choice with a control solution. These results suggest that voluntary nicotine drinking induces nicotine preference in mice, but does not alter a number of affective behaviors. In addition, alterations in CREB and GluR1 levels are not sufficient to explain preference for nicotine in a 2-bottle choice paradigm.
- Subjects :
- Administration, Oral
Animals
Anxiety Disorders drug therapy
Anxiety Disorders metabolism
Anxiety Disorders physiopathology
Behavior, Animal drug effects
Behavior, Animal physiology
Brain metabolism
Brain physiopathology
Cyclic AMP Response Element-Binding Protein drug effects
Cyclic AMP Response Element-Binding Protein metabolism
Depressive Disorder metabolism
Depressive Disorder physiopathology
Down-Regulation drug effects
Down-Regulation physiology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Motor Activity drug effects
Motor Activity physiology
Neural Pathways drug effects
Nicotinic Agonists pharmacology
Nucleus Accumbens drug effects
Nucleus Accumbens metabolism
Receptors, AMPA metabolism
Reward
Synaptic Transmission drug effects
Synaptic Transmission physiology
Tobacco Use Disorder physiopathology
Ventral Tegmental Area drug effects
Ventral Tegmental Area metabolism
Volition drug effects
Volition physiology
Brain drug effects
Depressive Disorder drug therapy
Glutamic Acid metabolism
Nicotine pharmacology
Receptors, AMPA drug effects
Tobacco Use Disorder metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 434
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 18261852
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.01.021