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PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes.
- Source :
-
Neuroscience letters [Neurosci Lett] 2008 Mar 21; Vol. 434 (1), pp. 50-5. Date of Electronic Publication: 2008 Jan 17. - Publication Year :
- 2008
-
Abstract
- The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity. We attempted to replicate these associations, testing cognitive function and lifetime cognitive change in 519 participants who took the same cognitive test at ages 11 and 79 years. Scores were also available for other cognitive tests at age 79 years, along with history of diabetes, current Body Mass Index (BMI), and other disease and demographic variables. Pro12Ala carrier status was not directly associated with diabetes history or BMI. In carriers who contracted diabetes despite carrying the protective allele, cognitive decline as measured by one test was significantly greater than in other groups. Only six individuals fell into this group; the other cognitive tests did not show this effect. This sample did not replicate the direct association of the PPARG Pro12Ala allele with diabetes status or preserved cognitive function. The data did suggest that risk of cognitive decline is greater when Pro12Ala carriers contract diabetes.
- Subjects :
- Aged
Aged, 80 and over
Aging metabolism
Amino Acid Substitution genetics
Child
Cognition Disorders metabolism
Cognition Disorders physiopathology
DNA Mutational Analysis
Dementia genetics
Dementia metabolism
Dementia physiopathology
Diabetes Complications metabolism
Diabetes Complications physiopathology
Female
Gene Frequency genetics
Genetic Testing
Genotype
Heterozygote
Humans
Male
Mutation genetics
Neuropsychological Tests
Polymorphism, Genetic genetics
Risk Factors
Aging genetics
Cognition Disorders genetics
Diabetes Complications genetics
Genetic Predisposition to Disease genetics
PPAR gamma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 434
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 18280041
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.01.027