Back to Search
Start Over
[Expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-3 and nm23-H1 in oral squamous cell carcinoma].
- Source :
-
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology [Zhonghua Kou Qiang Yi Xue Za Zhi] 2007 Nov; Vol. 42 (11), pp. 681-3. - Publication Year :
- 2007
-
Abstract
- Objective: To explore the role of vascular endothelial growth factor C (VEGF-C), VEGFR-3 and nm23-H(1) in lymphatic metastasis of oral squamous cell carcinoma (OSCC).<br />Methods: The expression of VEGF-C, VEGFR-3 and nm23-H(1) were examined by immunohistochemical SP method. The lymphatic vessels density (LVD) in tumors was counted and analyzed with clinicopathologic parameters.<br />Results: VEGF-C, LVD and nm23-H(1) expressions were significantly different between OSCC and benign and precancerous lesions (P < 0.05). VEGF-C was correlated with lymph node metastasis and LVD (P < 0.01). nm23-H(1) was related to clinical stage, histological grade and lymphatic metastasis (P < 0.05).<br />Conclusions: The high expressions of VEGF-C/VEGFR-3 and inactivation of nm23-H(1) may play an important role in lymphatic metastasis in OSCC.
- Subjects :
- Carcinoma, Squamous Cell pathology
Female
Humans
Lymphatic Metastasis pathology
Male
Mouth Neoplasms pathology
Carcinoma, Squamous Cell metabolism
Mouth Neoplasms metabolism
NM23 Nucleoside Diphosphate Kinases metabolism
Vascular Endothelial Growth Factor C metabolism
Vascular Endothelial Growth Factor Receptor-3 metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1002-0098
- Volume :
- 42
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
- Publication Type :
- Academic Journal
- Accession number :
- 18307927