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Roles of TNF-alpha gene polymorphisms in the occurrence and progress of SARS-Cov infection: a case-control study.
- Source :
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BMC infectious diseases [BMC Infect Dis] 2008 Feb 29; Vol. 8, pp. 27. Date of Electronic Publication: 2008 Feb 29. - Publication Year :
- 2008
-
Abstract
- Background: Host genetic factors may play a role in the occurrence and progress of SARS-Cov infection. This study was to investigate the relationship between tumor necrosis factor (TNF)-alpha gene polymorphisms with the occurrence of SARS-CoV infection and its role in prognosis of patients with lung interstitial fibrosis and femoral head osteonecrosis.<br />Methods: The association between genetic polymorphisms of TNF-alpha gene and susceptibility to severe acute respiratory syndromes (SARS) was conducted in a hospital-based case-control study including 75 SARS patients, 41 health care workers and 92 healthy controls. Relationships of TNF-alpha gene polymorphisms with interstitial lung fibrosis and femoral head osteonecrosis were carried out in two case-case studies in discharged SARS patients. PCR sequencing based typing (PCR-SBT) method was used to determine the polymorphisms of TNF-alpha gene in locus of the promoter region and univariate logistic analysis was conducted in analyzing the collected data.<br />Results: Compared to TT genotype, the CT genotype at the -204 locus was found associated with a protective effect on SARS with OR(95%CI) of 0.95(0.90-0.99). Also, TT genotype, CT and CC were found associated with a risk effect on femoral head necrosis with ORs(95%CI) of 5.33(1.39-20.45) and 5.67(2.74-11.71), respectively and the glucocorticoid adjusted OR of CT was 5.25(95%CI 1.18-23.46) and the combined (CT and CC) genotype OR was 6.0 (95%CI 1.60-22.55) at -1031 site of TNF-alpha gene. At the same time, the -863 AC genotype was manifested as another risk effect associated with femoral head necrosis with OR(95%CI) of 6.42(1.53-26.88) and the adjusted OR was 8.40(95%CI 1.76-40.02) in cured SARS patients compared to CC genotype.<br />Conclusion: SNPs of TNF-alpha gene of promoter region may not associate with SARS-CoV infection. And these SNPs may not affect interstitial lung fibrosis in cured SARS patients. However, the -1031CT/CC and -863 AC genotypes may be risk factors of femoral head necrosis in discharged SARS patients.
- Subjects :
- Adolescent
Adult
Aged
Case-Control Studies
China epidemiology
Female
Femur Head Necrosis complications
Genotype
Glucocorticoids administration & dosage
Humans
Logistic Models
Male
Middle Aged
Polymerase Chain Reaction
Prognosis
Promoter Regions, Genetic genetics
Pulmonary Fibrosis complications
Severe acute respiratory syndrome-related coronavirus pathogenicity
Severe Acute Respiratory Syndrome complications
Severe Acute Respiratory Syndrome drug therapy
Femur Head Necrosis genetics
Polymorphism, Genetic
Pulmonary Fibrosis genetics
Severe Acute Respiratory Syndrome genetics
Tumor Necrosis Factor-alpha genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18312678
- Full Text :
- https://doi.org/10.1186/1471-2334-8-27