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6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2008 Apr; Vol. 49 (4), pp. 573-86. Date of Electronic Publication: 2008 Mar 14. - Publication Year :
- 2008
-
Abstract
- In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors. This application is based on the unique property of neuroendocrine tumors to produce and secrete various substances, a process that requires the uptake of metabolic precursors, which leads to the uptake of 18F-DOPA. This nonsystematic review first describes basic aspects of 18F-DOPA imaging, including radiosynthesis, factors involved in tracer uptake, and various aspects of metabolism and imaging. Subsequently, this review provides an overview of current clinical applications in neuroendocrine tumors, including carcinoid tumors, pancreatic islet cell tumors, pheochromocytoma, paraganglioma, medullary thyroid cancer, hyperinsulinism, and various other clinical entities. The application of PET/CT in carcinoid tumors has unsurpassed sensitivity. In medullary thyroid cancer, pheochromocytoma, and hyperinsulinism, results are also excellent and contribute significantly to clinical management. In the remaining conditions, the initial experience with 18F-DOPA PET indicates that it seems to be less valuable, but further study is required.
- Subjects :
- Adenoma, Islet Cell diagnostic imaging
Humans
Hyperinsulinism diagnostic imaging
Pancreatic Neoplasms diagnostic imaging
Pheochromocytoma diagnostic imaging
Thyroid Neoplasms diagnostic imaging
Dihydroxyphenylalanine analogs & derivatives
Neuroendocrine Tumors diagnostic imaging
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5505
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 18344441
- Full Text :
- https://doi.org/10.2967/jnumed.107.045708