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DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2009 Dec; Vol. 30 (12), pp. 2000-9. Date of Electronic Publication: 2008 Mar 24. - Publication Year :
- 2009
-
Abstract
- Genetic association of the dynamin binding protein gene (DNMBP) on chromosome 10 with late-onset Alzheimer's disease (AD) was reported among Japanese. Here, we assessed the genetic role of DNMBP in an extended Belgian AD group using a gene-wide association approach. A total of 18 SNPs across the DNMBP locus were genotyped in 555 late-onset AD patients and 638 healthy control individuals. Significant associations were observed for two SNPs (rs3740057 and rs10883421). Haplotype analysis identified association with haplotype blocks in the 3' region of DNMBP comprising rs2862919, rs11190302, rs10509739, rs2256700 and comprising rs3740057 and rs6584331. Stratification for APOE epsilon4 status showed that association was only present in the APOE epsilon4 negative subgroup. Sliding-window analyses provided further evidence for association with the 3'-end of DNMBP both for the total and for the APOE epsilon4 negative group. Taken together our findings underscore a role for DNMBP in the genetic risk for late-onset AD in the Belgian population.
- Subjects :
- Aged
Alzheimer Disease epidemiology
Apolipoprotein E4 genetics
Belgium epidemiology
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Alzheimer Disease genetics
Cytoskeletal Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 30
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 18359537
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2008.02.003