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Bone generation in the reconstruction of a critical size calvarial defect in an experimental model.
- Source :
-
The Journal of craniofacial surgery [J Craniofac Surg] 2008 Mar; Vol. 19 (2), pp. 383-92. - Publication Year :
- 2008
-
Abstract
- This study was designed to investigate the optimal combination of known osteogenic biomaterials with shape conforming struts to achieve calvarial vault reconstruction, using a canine model. Eighteen adolescent beagles were divided equally into 6 groups. A critical-size defect of 6 x 2 cm traversed the sagittal suture. The biomaterials used for calvarial reconstruction were demineralized perforated bone matrix (DBM), recombinant human bone morphogenetic protein 2 (rhBMP2), and autogenous platelet-rich plasma (PRP). The struts used were cobalt chrome (metal) or resorbable plate. The groupings were as follows: 1) DBM + metal, 2) DBM + PRP + metal, 3) DBM + PRP + resorbable plate, 4) DBM + rhBMP2 + metal, 5) DBM + rhBMP2 + PRP + metal, and 6) DBM + rhBMP2 + resorbable plate. Animals were killed at 3 months after surgery. There was no mortality or major complications. Analysis was performed macroscopically and histologically and with computed tomography. There was complete bony regeneration in the rhBMP2 groups only. Non-rhBMP2 groups had minimal bony ingrowth from the defect edges and on the dural surface, a finding confirmed by computed tomographic scan and histology. Platelet-rich plasma did not enhance bone regeneration. Shape conformation was good with both metal and resorbable plate. rhBMP2, but not PRP, accelerated calvarial regeneration in 3 months. The DBMs in the rhBMP2 groups were substituted by new trabecular bone. Shape molding was good with both metal and resorbable plate.
- Subjects :
- Absorbable Implants
Animals
Biocompatible Materials therapeutic use
Bone Diseases pathology
Bone Matrix transplantation
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins therapeutic use
Bone Plates
Bone Regeneration drug effects
Bone Regeneration physiology
Chromium Alloys
Coloring Agents
Cranial Sutures surgery
Disease Models, Animal
Dogs
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Lactic Acid
Male
Osteogenesis drug effects
Platelet-Rich Plasma
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Recombinant Proteins therapeutic use
Skull pathology
Tomography, X-Ray Computed
Transforming Growth Factor beta therapeutic use
Bone Diseases surgery
Osteogenesis physiology
Plastic Surgery Procedures methods
Skull surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1049-2275
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of craniofacial surgery
- Publication Type :
- Academic Journal
- Accession number :
- 18362715
- Full Text :
- https://doi.org/10.1097/SCS.0b013e318163e415