Back to Search
Start Over
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
- Source :
-
Nature genetics [Nat Genet] 2008 May; Vol. 40 (5), pp. 623-30. Date of Electronic Publication: 2008 Mar 30. - Publication Year :
- 2008
-
Abstract
- To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition.
- Subjects :
- Adult
Aged
Alleles
Eukaryotic Initiation Factor-3 genetics
Female
Genetic Linkage
Humans
Male
Middle Aged
Pedigree
Chromosomes, Human, Pair 10 genetics
Chromosomes, Human, Pair 8 genetics
Colorectal Neoplasms genetics
Genetic Predisposition to Disease
Genome, Human
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 40
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 18372905
- Full Text :
- https://doi.org/10.1038/ng.111