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Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis.
- Source :
-
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2008 Oct; Vol. 18 (5), pp. 369-378. Date of Electronic Publication: 2008 Apr 02. - Publication Year :
- 2008
-
Abstract
- Objective: To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA.<br />Design: This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F,10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA).<br />Results: Median adjusted height (AHt) SDS was -0.3 (-2.2 to 1.6). Serum ALS SDS (median -1.3, range -2.7 to -0.6) was reduced compared with serum IGFBP-3 SDS (median -0.5, range -7.7 to 2.3) and IGF-1 SDS (median -0.2, range -0.5 to 0.5). Log serum IL5 (95% CI -3.25, -0.81) and log serum IL15 (95% CI -9.58, -4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS.<br />Conclusion: Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.
- Subjects :
- Adolescent
Arthritis, Juvenile immunology
Body Height
Child
Child, Preschool
Cross-Sectional Studies
Female
Growth Disorders metabolism
Humans
Inflammation blood
Insulin-Like Growth Factor I metabolism
Interleukin-5 blood
Interleukin-6 blood
Male
Prospective Studies
Puberty
Arthritis, Juvenile blood
Cytokines blood
Insulin-Like Growth Factor Binding Proteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1096-6374
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 18378173
- Full Text :
- https://doi.org/10.1016/j.ghir.2008.01.006