Intraperitoneal administration of gonadotropin-releasing hormone-PE40 induces castration in male rats.

Authors :: Yu L
Zhang ZF
Jing CX
Wu FL
Source :: World journal of gastroenterology [World J Gastroenterol] 2008 Apr 07; Vol. 14 (13), pp. 2106-9.
Publication Year :: 2008
Abstract: Aim: To evaluate the long-term effects of gonadotropinreleasing hormone (GnRH)-based vaccine on levels of GnRH antibody and testosterone, and vaccine-induced immunocastration on sexual behavior of male rats.<br />Methods: The rats were treated with GnRH-PE40 intraperitoneally every other day for 12 wk. GnRH antibody and testosterone level in rat blood were determined by ELISA and radioimmunoassay, respectively. Morphological changes in testes and sexual behavior of rats were evaluated.<br />Results: GnRH-PE40 induced a high production in GnRH antibody, decreased the serum testosterone level, testis atrophy and sexual function in rats.<br />Conclusion: Intraperitoneal administration of GnRHPE40 produces structural and functional castration of male rat reproductive system by inducing anti-GnRH antibody.

Subjects :: Animals
Castration
Exotoxins pharmacology
Injections, Intraperitoneal
Male
Peptides chemistry
Rats
Rats, Wistar
Sexual Behavior, Animal drug effects
Spermatogenesis drug effects
Spermatozoa metabolism
Testis metabolism
Testosterone metabolism
Time Factors
Treatment Outcome
Exotoxins metabolism
Gonadotropin-Releasing Hormone chemistry

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