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Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2008 May 01; Vol. 197 (9), pp. 1333-40. - Publication Year :
- 2008
-
Abstract
- Background: In areas where intestinal helminth infections are endemic, infections by these parasites may protect against skin test-measured reactivity to allergens, and it has been suggested that interleukin (IL)-10 may mediate this effect. This study investigated whether IL-10 and populations of IL-10+ T cells may modulate atopy in children living in an area where intestinal helminth infections are endemic.<br />Methods: Ecuadorian schoolchildren from rural communities were assessed for skin test-measured reactivity to Periplaneta americana allergen and Dermatophagoides pteronyssinus allergen. Blood samples were collected from 39 skin test-positive and 41 skin test-negative children, and peripheral-blood leukocytes were cultured in the presence of Ascaris lumbricoides antigen, to measure IL-10 protein and the frequency of T cell populations expressing intracellular IL-10. We also investigated whether these immunological factors affected the association between allergen-specific IgE and skin test-measured reactivity to aeroallergens.<br />Results: There was no evidence of association between the level of A. lumbricoides-induced IL-10 protein or IL-10+ T cells and skin test-measured reactivity to allergens. The association between allergen-specific IgE and skin test-measured reactivity was not affected by the level of IL-10 protein or the frequency of IL-10+ T cells.<br />Conclusions: The results of this study do not support the notion that IL-10 plays a role in modulating atopy in children living in a tropical area where intestinal helminth infections are endemic.
- Subjects :
- Animals
Antibodies, Helminth blood
Child
Cross-Sectional Studies
Female
Humans
Interleukin-10 immunology
Leukocytes, Mononuclear immunology
Leukocytes, Mononuclear metabolism
Male
Rural Population
Skin Tests
Ascariasis immunology
Ascaris lumbricoides immunology
Hypersensitivity prevention & control
Interleukin-10 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 197
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18422446
- Full Text :
- https://doi.org/10.1086/586904