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Association between fatty acid binding protein 3 gene variants and essential hypertension in humans.
- Source :
-
American journal of hypertension [Am J Hypertens] 2008 Jun; Vol. 21 (6), pp. 691-5. Date of Electronic Publication: 2008 Apr 10. - Publication Year :
- 2008
-
Abstract
- Background: We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.<br />Methods: We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data.<br />Results: The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences.<br />Conclusion: We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.
Details
- Language :
- English
- ISSN :
- 0895-7061
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 18437121
- Full Text :
- https://doi.org/10.1038/ajh.2008.40