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Cell-specific integration of artificial organelles based on functionalized polymer vesicles.
- Source :
-
Nano letters [Nano Lett] 2008 May; Vol. 8 (5), pp. 1368-73. Date of Electronic Publication: 2008 Apr 30. - Publication Year :
- 2008
-
Abstract
- Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell.
Details
- Language :
- English
- ISSN :
- 1530-6984
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 18444692
- Full Text :
- https://doi.org/10.1021/nl080105g