Back to Search Start Over

Cell-specific integration of artificial organelles based on functionalized polymer vesicles.

Authors :
Ben-Haim N
Broz P
Marsch S
Meier W
Hunziker P
Source :
Nano letters [Nano Lett] 2008 May; Vol. 8 (5), pp. 1368-73. Date of Electronic Publication: 2008 Apr 30.
Publication Year :
2008

Abstract

Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell.

Details

Language :
English
ISSN :
1530-6984
Volume :
8
Issue :
5
Database :
MEDLINE
Journal :
Nano letters
Publication Type :
Academic Journal
Accession number :
18444692
Full Text :
https://doi.org/10.1021/nl080105g