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Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.
- Source :
-
Head & neck [Head Neck] 2008 Jul; Vol. 30 (7), pp. 946-63. - Publication Year :
- 2008
-
Abstract
- Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein-Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen-activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E-cadherin and beta-catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p16, cyclin D1, and cyclin E. Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments.
- Subjects :
- Cadherins genetics
Carcinogenicity Tests methods
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Cell Proliferation
Cyclin E genetics
Female
Gene Expression Regulation, Neoplastic
Herpesvirus 4, Human genetics
Humans
Male
Molecular Biology
NF-kappa B p50 Subunit genetics
Nasopharyngeal Neoplasms epidemiology
Nasopharyngeal Neoplasms pathology
Oncogene Proteins genetics
Sensitivity and Specificity
Signal Transduction genetics
beta Catenin genetics
Apoptosis genetics
Carcinoma, Squamous Cell genetics
Genetic Predisposition to Disease epidemiology
Nasopharyngeal Neoplasms genetics
Proto-Oncogene Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 18446839
- Full Text :
- https://doi.org/10.1002/hed.20833