Activation of natural Hf and Ta in relation to the production of 177Lu.

Authors :: Medvedev DG
Mausner LF
Greene GA
Hanson AL
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2008 Oct; Vol. 66 (10), pp. 1300-6. Date of Electronic Publication: 2008 Mar 07.
Publication Year :: 2008
Abstract: The isotope (177)Lu is used in nuclear medicine and biology for in vivo applications as a radioactive label of various targeting agents. To extend the availability of no-carrier added (177)Lu, we investigated the feasibility of its production in a proton accelerator. Tantalum and Hf targets were irradiated and chemically processed to determine the radioisotope yield and cross-sections. The largest cross-sections (approximately 20 mb) were found for the Hf target at 195 MeV; however, the presence of co-produced Lu isotopes may limit the product applications. The results are in good agreement with theoretical data calculated using computer codes MCNPX and ORIGEN2S. Production of relevant medical isotopes such as (167)Tm and (169)Yb from the above targets is discussed as well.

Subjects :: Computer Simulation
Feasibility Studies
Hafnium radiation effects
Tantalum radiation effects
Hafnium chemistry
Lutetium chemistry
Models, Chemical
Radioisotopes chemistry
Tantalum chemistry

Language :: English
ISSN :: 0969-8043
Volume :: 66
Issue :: 10
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 18456503
Full Text :: https://doi.org/10.1016/j.apradiso.2008.02.090