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Ergotamine-derived dopamine agonists and left ventricular function in Parkinson patients: systolic and diastolic function studied by conventional echocardiography, tissue Doppler imaging, and two-dimensional speckle tracking.
- Source :
-
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology [Eur J Echocardiogr] 2008 Nov; Vol. 9 (6), pp. 803-8. Date of Electronic Publication: 2008 May 07. - Publication Year :
- 2008
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Abstract
- Aims: Ergot-derived dopamine agonists (EDDA) induce fibrotic heart valve disease. We aimed to investigate whether EDDA treatment also affects left ventricular (LV) function.<br />Methods and Results: Myocardial function was evaluated in 110 Parkinson patients [mean age (63.4 +/- 9.0 years)] treated for at least 6 months with either EDDA (n = 71) or non-EDDA (n = 39). LV ejection fraction did not differ between EDDA and non-EDDA patients [63 +/- 4% vs. 65 +/- 4% (ns)]. There was no difference in prevalence of diastolic dysfunction between EDDA and non-EDDA patients [7% vs. 8% (ns)]. Finally, averaged LV systolic myocardial strain and longitudinal displacement analysed by means of two-dimensional speckle tracking showed no difference between EDDA and non-EDDA patients [strain: 19 +/- 3% vs. 19 +/- 2% (ns) and longitudinal displacement: 12 +/- 2 mm vs. 12 +/- 2 mm (ns)]. Elevated p-NT-proBNP was found in 38% of EDDA patients and in 59% of non-EDDA patients (ns).<br />Conclusion: In contrast to the well-established association between EDDA treatment and valvular fibrosis, EDDA did not have a detectable adverse impact on myocardial systolic and diastolic function.
- Subjects :
- Aged
Analysis of Variance
Biomarkers blood
Diastole
Dopamine Agonists therapeutic use
Echocardiography, Doppler, Pulsed
Ergotamine therapeutic use
Female
Heart Valve Diseases diagnostic imaging
Humans
Male
Middle Aged
Multivariate Analysis
Natriuretic Peptide, Brain blood
Parkinson Disease blood
Parkinson Disease drug therapy
Retrospective Studies
Systole
Ventricular Dysfunction, Left diagnostic imaging
Dopamine Agonists adverse effects
Echocardiography methods
Ergotamine adverse effects
Image Interpretation, Computer-Assisted methods
Parkinson Disease diagnostic imaging
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2114
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 18490274
- Full Text :
- https://doi.org/10.1093/ejechocard/jen160