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[Delayed effect of exorphins on learning of albino rat pups].
- Source :
-
Izvestiia Akademii nauk. Seriia biologicheskaia [Izv Akad Nauk Ser Biol] 2008 Jan-Feb (1), pp. 53-60. - Publication Year :
- 2008
-
Abstract
- The delayed effect of food-derived opioid peptides (exorphins) after chronic administration on postnatal days 1-14 on the learning of albino rat pups has been studied. Heptapeptide YPFPGPI (beta-casomorphin-7), pentapeptide YPLDL (rubiscolin-5) and pentapeptide YPISL (exorphin C) improved the development of the conditioned foraging reflex in a complex maze. Hexapeptide PFPGPI lacking the N-terminal tyrosine proved inefficient. Only beta-casomorphin-7 had an effect (negative) on passive avoidance conditioning. The obtained data confirm that exorphins (particularly, milk-derived beta-casomorphins) can have significant and long-term effects on the environmental adaptation of young mammals.
Details
- Language :
- Russian
- ISSN :
- 1026-3470
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Izvestiia Akademii nauk. Seriia biologicheskaia
- Publication Type :
- Academic Journal
- Accession number :
- 18491562