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Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes.
- Source :
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British journal of haematology [Br J Haematol] 2008 Jun; Vol. 142 (2), pp. 216-26. Date of Electronic Publication: 2008 May 19. - Publication Year :
- 2008
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Abstract
- To further characterize the genotypic features of splenic (S) and nodal (N) marginal zone lymphomas (MZL) we compared eight SMZL and five NMZL by array-based comparative genomic hybridization (aCGH). Arbitrarily, aberrations were divided into major imbalances, defined as gains or losses involving five or more contiguous genetic loci, and minor imbalances, defined as those involving four or fewer loci. SMZL, but not NMZL, demonstrated major imbalances. These included deletions involving various lengths of 7q (three cases), and 14q23q24 (one case) and gains of 9p13p21 (one case), 13q21q33 (one case) and 16p13.1 (one case). Common minor imbalances in SMZL were: loss of sonic hedgehog gene (SHH) at 7q36.2 (four cases), loss of protection of telomere 1 gene (POT1) at 7q31.32 (three cases), and gain of glioma associated oncogene 1 (GLI1) at 12q13.2 (three cases). Common minor alterations in NMZL were: loss of the fas-associated via death domain gene (FADD) at 11q13.2 (three cases) and gain of GLI1 (five cases). In conclusion, SMZL, but not NMZL, demonstrates large genomic imbalances and frequent loss of the 7q31.32 and 7q36.2 regions involving POT1 and SHH, respectively. In NMZL, loss of FADD and gain of GLI1 are frequent events.
- Subjects :
- Aged
Comparative Genomic Hybridization methods
DNA Mutational Analysis
DNA, Neoplasm genetics
DNA, Neoplasm isolation & purification
Female
Hedgehog Proteins genetics
Hedgehog Proteins physiology
Humans
In Situ Hybridization, Fluorescence
Lymphatic Diseases physiopathology
Lymphoma, B-Cell, Marginal Zone physiopathology
Male
Middle Aged
Nucleic Acid Hybridization methods
Oligonucleotide Array Sequence Analysis methods
Reverse Transcriptase Polymerase Chain Reaction
Shelterin Complex
Splenic Neoplasms physiopathology
Telomere genetics
Telomere-Binding Proteins genetics
Telomere-Binding Proteins physiology
Chromosomes, Human, Pair 7 genetics
Lymphatic Diseases genetics
Lymphoma, B-Cell, Marginal Zone genetics
Splenic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 142
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 18492102
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2008.07176.x