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Effects of denosumab on the geometry of the proximal femur in postmenopausal women in comparison with alendronate.
- Source :
-
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2008 Jul-Sep; Vol. 11 (3), pp. 351-9. Date of Electronic Publication: 2008 May 20. - Publication Year :
- 2008
-
Abstract
- Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, an essential mediator of osteoclast activity and survival. In postmenopausal women with low bone mineral density (BMD), subcutaneous denosumab decreases bone resorption and increases BMD. This post hoc analysis reports on subjects treated for up to 24 months with denosumab 60mg 6 monthly (N=39), placebo (N=39), or open-label alendronate 70mg once weekly (N=38) in a phase 2 study. Hip scans were done by dual-energy X-ray absorptiometry at baseline, 12, and 24 months; these were analyzed with hip structural analysis software to evaluate BMD and cross-sectional geometry parameters at the narrowest segment of the femoral neck, the intertrochanter, and the proximal shaft. Geometric parameters and derived strength indices included bone cross-sectional area, section modulus, and buckling ratio. At 12 and 24 months denosumab and alendronate improved these parameters compared with placebo. Denosumab effects were greater than alendronate at the intertrochanteric and shaft sites. The magnitude and direction of the changes in structural geometry parameters observed in this study suggest that denosumab treatment may lead to improved bone mechanical properties. Ongoing phase 3 studies will determine whether denosumab reduces fracture risk.
- Subjects :
- Absorptiometry, Photon
Alendronate administration & dosage
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal, Humanized
Bone Density Conservation Agents administration & dosage
Denosumab
Female
Humans
Least-Squares Analysis
Middle Aged
RANK Ligand administration & dosage
Treatment Outcome
Alendronate pharmacology
Antibodies, Monoclonal pharmacology
Bone Density drug effects
Bone Density Conservation Agents pharmacology
Femur drug effects
Osteoporosis, Postmenopausal drug therapy
RANK Ligand pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1094-6950
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
- Publication Type :
- Academic Journal
- Accession number :
- 18495508
- Full Text :
- https://doi.org/10.1016/j.jocd.2008.04.001