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Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression.
- Source :
-
International journal of cancer [Int J Cancer] 2008 Aug 01; Vol. 123 (3), pp. 609-15. - Publication Year :
- 2008
-
Abstract
- In this study we investigated whether the presence of specific populations of tumor infiltrating lymphocytes (TILs) in diagnostic primary melanoma biopsies are related to outcome in clinically stage II melanoma patients. Moreover, we investigated whether the presence of TILs correlates with expression of MHC class I antigen and MHC class II antigen on tumor cells and/or tumor infiltrating antigen presenting cells. Diagnostic primary melanoma samples of 15 patients with an unfavorable outcome were compared with 20 patients with favorable outcome. Patients were matched for age, gender and Breslow thickness. Biopsies were examined for the presence of granzyme B+, CD8+, CD4+ and CD56+ TILs and for expression of MHC class I antigen and MHC class II antigen on tumor and/or tumor infiltrating cells. A favorable clinical outcome was strongly associated with the presence of GrB+ and CD4+ TILs, with expression of MHC class I antigen on tumor cells and with expression of MHC class II antigen on intratumoral antigen presenting cells. These data strongly support the notion that in melanoma patients the cellular immune response is a major factor in preventing melanoma cell dissemination.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigen-Presenting Cells immunology
Biopsy
CD4 Antigens analysis
CD56 Antigen analysis
CD8 Antigens analysis
Female
Granzymes analysis
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Treatment Outcome
Biomarkers, Tumor analysis
Histocompatibility Antigens Class I analysis
Histocompatibility Antigens Class II analysis
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating
Melanoma immunology
Melanoma pathology
Skin Neoplasms immunology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 123
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18498132
- Full Text :
- https://doi.org/10.1002/ijc.23543