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Galanin acts as a trophic factor to the central and peripheral nervous systems.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2008 Jun; Vol. 65 (12), pp. 1806-12. - Publication Year :
- 2008
-
Abstract
- The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous system. Its expression is markedly upregulated in many neuronal tissues after nerve injury or disease. Over the last 10 years we have demonstrated that the peptide plays a developmental survival role to subsets of neurons in the peripheral and central nervous systems with resulting phenotypic changes in neuropathic pain and cognition. Galanin also appears to play a trophic role to adult sensory neurons following injury, via activation of GalR2, by stimulating neurite outgrowth. Furthermore, galanin also plays a neuroprotective role to the hippocampus following excitotoxic injury, again mediated by activation of GalR2. In summary, these studies demonstrate that a GalR2 agonist might have clinical utility in a variety of human diseases that affect the nervous system.
- Subjects :
- Cell Survival
Enhancer Elements, Genetic
Galanin genetics
Galanin metabolism
Humans
Neurites physiology
Neuroprotective Agents pharmacology
Nociceptors cytology
Receptor, Galanin, Type 2 metabolism
Central Nervous System cytology
Galanin physiology
Nerve Growth Factors physiology
Peripheral Nervous System cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-682X
- Volume :
- 65
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 18500646
- Full Text :
- https://doi.org/10.1007/s00018-008-8154-7