Back to Search
Start Over
4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2008 Mar; Vol. 61 (3), pp. 175-84. - Publication Year :
- 2008
-
Abstract
- 18-amino-4''-O-benzoyl-4'''-N-demethyl-18-deoxospiramycins were designed and synthesized. Synthetic strategy involved selective demethylation of the dimethylamino group in forosamine, benzoylation of the hydroxyl group at the C4'' position and reductive N-amination of the formyl group. Antibacterial characteristics of spiramycin derivatives were tested. The derivatives exhibited promising activity against drug-resistant bacterial strains.
- Subjects :
- Carbohydrate Sequence
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Methicillin Resistance
Microbial Sensitivity Tests
Molecular Sequence Data
Spectrophotometry, Infrared
Spiramycin chemical synthesis
Spiramycin pharmacology
Staphylococcus aureus drug effects
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Bacteria drug effects
Drug Resistance, Bacterial drug effects
Spiramycin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 61
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 18503196
- Full Text :
- https://doi.org/10.1038/ja.2008.127