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HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation.
- Source :
-
Transplant immunology [Transpl Immunol] 2008 May; Vol. 19 (2), pp. 152-7. Date of Electronic Publication: 2008 Mar 31. - Publication Year :
- 2008
-
Abstract
- Background: Monocytes mediate immune responses following solid organ transplantation via cytokine secretion and differentiation to macrophage/dendritic cell lineages. To date, the pleiotropic immunomodulatory effect of statins on human monocytes following human heart transplantation has yet to be elucidated. This study was designed to assess the effects of statin administration on the monocyte repertoire.<br />Methods: 108 patients were recruited into the study. Clinical data were collected from patients' notes. Peripheral blood immunophenotype was determined via flow cytometry (using CD11c, CD14, CD16, CD49d, CD64, CD80 and CD195).<br />Results: There were fewer circulating classical (p=0.0001) and non-classical (p=0.0013) monocytes in patients treated with a statin. CD64 expression was down-regulated (p=0.011 and p=0.049) whereas CD49d expression was up-regulated (p=0.004 and p=0.022) on classical and non-classical monocytes in this group. Patients receiving Atorvastatin had fewer circulating classical monocytes (p=0.001) compared to patients administered Pravastatin. Patients receiving Pravastatin had fewer circulating non-classical monocytes (p=0.029) compared to patients administered Atorvastatin.<br />Discussion: Statin administration alters the circulating monocyte repertoire following heart transplantation, including population size, FcgammaRI and VLA-4 adhesion molecule expression. Furthermore, different statin treatments are associated with a selective depletion of macrophage or DC (re)generating monocytes.
- Subjects :
- Adult
Aged
Atorvastatin
Cross-Sectional Studies
Down-Regulation
Female
Heptanoic Acids pharmacology
Heptanoic Acids therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Integrin alpha4 immunology
Leukocyte Count
Male
Middle Aged
Monocytes drug effects
Monocytes metabolism
Pravastatin pharmacology
Pravastatin therapeutic use
Pyrroles pharmacology
Pyrroles therapeutic use
Receptors, IgG immunology
Up-Regulation
Heart Transplantation immunology
Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology
Integrin alpha4 metabolism
Monocytes immunology
Receptors, IgG metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0966-3274
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Transplant immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18503891
- Full Text :
- https://doi.org/10.1016/j.trim.2008.02.002