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Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort.
- Source :
-
Stroke [Stroke] 2008 Aug; Vol. 39 (8), pp. 2268-73. Date of Electronic Publication: 2008 Jun 05. - Publication Year :
- 2008
-
Abstract
- Background and Purpose: The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH).<br />Methods: Risk factors were assessed at baseline in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) involving 21,680 adults aged 45 or over. Over 263,489 person-years of follow-up, we identified 135 incident ICH events.<br />Results: In multivariable models, for each SD higher baseline level of fibrinogen, the relative rate of incident ICH increased 35% (95% CI, 17% to 55%). Fibrinogen was more strongly related to ICH in ARIC than in CHS. In multivariable models, those with von Willebrand factor levels above the median were 1.72 (95% CI, 0.97 to 3.03) times more likely to have an incident ICH as those below the median. Factor VIII was significantly positively related to ICH in ARIC (relative rate per standard deviation of 1.31; 95% CI, 1.07 to 1.62), but not in CHS. There was no relation in multivariable models between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH.<br />Conclusions: Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of ICH in these prospective studies, whereas Factor VIII was related to ICH in younger ARIC study participants only.
- Subjects :
- Age Distribution
Aged
Biomarkers blood
C-Reactive Protein metabolism
Cerebral Hemorrhage immunology
Cohort Studies
Female
Follow-Up Studies
Humans
Leukocyte Count
Lipoprotein(a) blood
Male
Middle Aged
Multivariate Analysis
Prevalence
Risk Factors
Stroke immunology
United States epidemiology
Vasculitis blood
Vasculitis epidemiology
Vasculitis immunology
Cerebral Hemorrhage blood
Cerebral Hemorrhage epidemiology
Factor VIII metabolism
Fibrinogen metabolism
Stroke blood
Stroke epidemiology
von Willebrand Factor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 39
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 18535282
- Full Text :
- https://doi.org/10.1161/STROKEAHA.107.505800