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Selective enrichment of cysteine-containing peptides using SPDP-functionalized superparamagnetic Fe(3)O(4)@SiO(2) nanoparticles: application to comprehensive proteomic profiling.
- Source :
-
Journal of proteome research [J Proteome Res] 2008 Aug; Vol. 7 (8), pp. 3591-6. Date of Electronic Publication: 2008 Jun 19. - Publication Year :
- 2008
-
Abstract
- Superparamagnetic Fe(3)O(4)@SiO(2) core-shell nanoparticles (ca. 30 nm diameter), which are surface-modified with a thiol-specific functional group, exhibit superb capturing efficiency toward cysteinyl peptides without contamination from nonspecifically interacting peptides, as clearly evidenced through LC/MS/MS analysis.
Details
- Language :
- English
- ISSN :
- 1535-3893
- Volume :
- 7
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of proteome research
- Publication Type :
- Academic Journal
- Accession number :
- 18563925
- Full Text :
- https://doi.org/10.1021/pr800067x