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Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma.
- Source :
-
The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2008 Jun; Vol. 45 (5), pp. 383-8. - Publication Year :
- 2008
-
Abstract
- The aim of this study was to determine the influence of single nucleotide polymorphisms in the beta(2)-adrenoceptor gene, on the response to inhaled beta(2)-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to beta(2)-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for beta(2)Arg16Gly and beta(2)Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly beta(2)-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1 hourly: 2.6 hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6 hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8 hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to beta (2)-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways.
- Subjects :
- Adolescent
Asthma diagnosis
Asthma mortality
Child
Child, Preschool
Cohort Studies
Female
Genetic Predisposition to Disease epidemiology
Humans
Kaplan-Meier Estimate
Male
Predictive Value of Tests
Probability
Receptors, Adrenergic, beta-2 metabolism
Respiratory Function Tests
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Survival Analysis
Treatment Outcome
Adrenergic beta-Agonists administration & dosage
Asthma drug therapy
Asthma genetics
Polymorphism, Genetic
Receptors, Adrenergic, beta-2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4303
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of asthma : official journal of the Association for the Care of Asthma
- Publication Type :
- Academic Journal
- Accession number :
- 18569231
- Full Text :
- https://doi.org/10.1080/02770900801971792