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[Effects of rosiglitazone on inflammatory reaction and insulin resistance in obese patients with newly diagnosed type 2 diabetes].
- Source :
-
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2008 Jun; Vol. 28 (6), pp. 1050-1. - Publication Year :
- 2008
-
Abstract
- Objective: To study the effect of rosiglitazone on serum high-sensitivity C-reactive protein (hs-CRP), interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha) and insulin resistance in obese patients with newly diagnosed type 2 diabetes.<br />Methods: This study involved 118 patients with newly diagnosed type 2 diabetes and obesity, who were randomly assigned into two groups for a 12-week treatment with rosiglitazone (4 mg/day, group A) or sulfonylureas (group B). Serum hs-CRP, IL-1beta, IL-6, TNF-alpha, fasting plasma glucose (FPG) and fasting insulin (FINS) were measured before and after the treatment. Insulin resistance index was calculated according to the HOMA Model.<br />Results: In group A, rosiglitazone treatment resulted in significantly reduced serum hs-CRP, IL-1beta, IL-6, TNF-alpha, FPG and insulin resistance index (P<0.01). No difference in FPG was found between the two groups after the treatment (P>0.05), but serum hs-CRP, IL-1beta, IL-6, TNF-alpha and insulin resistance index were significantly lower in group A than in group B (P<0.05).<br />Conclusion: Rosiglitazone can decrease FPG, reduce the inflammation reaction and improve insulin resistance in obese patients with type 2 diabetes.
- Subjects :
- Adult
Aged
Aged, 80 and over
C-Reactive Protein metabolism
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Female
Humans
Hypoglycemic Agents therapeutic use
Inflammation blood
Interleukin-1beta blood
Interleukin-6 blood
Male
Middle Aged
Rosiglitazone
Tumor Necrosis Factor-alpha blood
Diabetes Mellitus, Type 2 drug therapy
Inflammation prevention & control
Insulin Resistance
Obesity complications
Thiazolidinediones therapeutic use
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1673-4254
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University
- Publication Type :
- Academic Journal
- Accession number :
- 18583261