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[Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2008 Apr; Vol. 33 (7), pp. 822-4. - Publication Year :
- 2008
-
Abstract
- Objective: To study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).<br />Method: Adopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.<br />Result: Intraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.<br />Conclusion: The result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).
- Subjects :
- Analgesics administration & dosage
Analgesics therapeutic use
Animals
Carbenoxolone administration & dosage
Carbenoxolone therapeutic use
Dose-Response Relationship, Drug
Female
Male
Mice
Mice, Inbred ICR
Pain drug therapy
Alkaloids chemistry
Analgesics chemistry
Analgesics pharmacology
Carbenoxolone chemistry
Carbenoxolone pharmacology
Quinolizines chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 33
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 18589792