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Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
- Source :
-
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2008 Nov; Vol. 102 (11), pp. 1151-3. Date of Electronic Publication: 2008 Jul 02. - Publication Year :
- 2008
-
Abstract
- We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
- Subjects :
- Animals
Artemisinins therapeutic use
Artesunate
Drug Resistance genetics
Genes, MDR genetics
Genotype
Humans
Malaria, Falciparum drug therapy
Mefloquine therapeutic use
Papua New Guinea
Plasmodium falciparum drug effects
Polymorphism, Genetic
Antimalarials therapeutic use
Malaria, Falciparum genetics
Multidrug Resistance-Associated Proteins genetics
Plasmodium falciparum genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3503
- Volume :
- 102
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 18599099
- Full Text :
- https://doi.org/10.1016/j.trstmh.2008.05.017