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The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke.
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2008 Oct; Vol. 396 (1-2), pp. 7-9. Date of Electronic Publication: 2008 Jun 15. - Publication Year :
- 2008
-
Abstract
- Background: The mechanisms of ischemic stroke in young adults are poorly understood. The main goal of the current investigation was to determine the possible contribution of genes affecting hemostasis, homocysteine metabolism and endothelial function on the occurrence of ischemic stroke in a cohort of young cases and corresponding controls.<br />Methods: We evaluated in 97 consecutive patients referred to our center between April 2006 and July 2007 for a history of young adult ischemic stroke (age at first event, <45 y) the prevalence of factor V Leiden, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T and endothelial nitric oxide synthase (eNOS) 4ab gene variants. Ninety-nine subjects age and gender matched (18 to 45 y) from other departments of the Tiantan Hospital served as controls.<br />Results: Homozygosity for the TT genotype of the MTHFR gene was 29 of 97 (29.9%) in patients and 34 of 99 (34.3%) in controls; this difference was not statistically significant (p>0.05, chi2). Variation of factor V Leiden was not detected both in patients and in controls of this cohort. Genotype eNOS 4bb was 90 of 97 (92.8%) in patients and 81 of 99 (81.8%) in controls; this difference was statistically significant (p<0.05, chi2 test).<br />Conclusions: The eNOS 4ab variant appears to be an important risk factor for ischemic stroke in young Chinese population.
- Subjects :
- Adolescent
Adult
China
Factor V genetics
Female
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Middle Aged
Mutation genetics
Nitric Oxide Synthase Type III genetics
Risk Factors
Factor V metabolism
Methylenetetrahydrofolate Reductase (NADPH2) metabolism
Nitric Oxide Synthase Type III metabolism
Polymorphism, Genetic genetics
Stroke genetics
Stroke metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0009-8981
- Volume :
- 396
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18602910
- Full Text :
- https://doi.org/10.1016/j.cca.2008.06.009