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Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters.
- Source :
-
AIDS (London, England) [AIDS] 2008 Jul 31; Vol. 22 (12), pp. 1515-7. - Publication Year :
- 2008
-
Abstract
- We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.
- Subjects :
- Antiretroviral Therapy, Highly Active
Female
Genetic Predisposition to Disease
HIV Infections drug therapy
HIV Infections virology
Humans
Milk, Human virology
RNA, Viral analysis
Viral Load
HIV Infections genetics
HIV-1 isolation & purification
Polymorphism, Single Nucleotide
beta-Defensins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 22
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18614876
- Full Text :
- https://doi.org/10.1097/QAD.0b013e3282fd6e0c