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Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway.
Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway.
- Source :
-
Journal of invertebrate pathology [J Invertebr Pathol] 2008 Nov; Vol. 99 (3), pp. 286-93. Date of Electronic Publication: 2008 Jun 24. - Publication Year :
- 2008
-
Abstract
- Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). After separation into an ACN-rich phase (ACN-extract) and an aqueous phase, and subsequent solid-phase extraction of the aqueous phase, fractions differing in polarity were obtained and screened for antibacterial and antifungal activities, along with the more lipophilic ACN-extracts. Antimicrobial activity was determined against two gram-negative, two gram-positive bacteria, and two strains of fungi. Notably, all the invertebrate species in the study showed activity against all four strains of bacteria and the two strains of fungi. In general, the aqueous fractions displayed highest antimicrobial activity, and the most potent extracts were obtained from the colonial ascidian Synoicum pulmonaria which displayed activity against bacteria and fungi at a concentration of 0.02 mg/ml; the lowest concentration tested.
- Subjects :
- Animals
Anthozoa chemistry
Anthozoa metabolism
Anti-Bacterial Agents isolation & purification
Antifungal Agents isolation & purification
Dose-Response Relationship, Drug
Humans
Invertebrates metabolism
Microbial Sensitivity Tests
Norway
Porifera chemistry
Porifera metabolism
Tissue Extracts isolation & purification
Urochordata chemistry
Urochordata metabolism
Anti-Bacterial Agents pharmacology
Antifungal Agents pharmacology
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Invertebrates chemistry
Tissue Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0805
- Volume :
- 99
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of invertebrate pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18621054
- Full Text :
- https://doi.org/10.1016/j.jip.2008.06.009