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4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 01; Vol. 18 (15), pp. 4316-20. Date of Electronic Publication: 2008 Jun 28. - Publication Year :
- 2008
-
Abstract
- 4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.
- Subjects :
- Animals
Combinatorial Chemistry Techniques
Drug Screening Assays, Antitumor
Humans
Isoenzymes
Mice
Molecular Structure
Morpholines chemical synthesis
Morpholines chemistry
Structure-Activity Relationship
Thiazoles chemical synthesis
Thiazoles chemistry
Xenograft Model Antitumor Assays
1-Phosphatidylinositol 4-Kinase antagonists & inhibitors
Morpholines pharmacology
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18625552
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.06.076