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Xenopus zinc finger transcription factor IA1 (Insm1) expression marks anteroventral noradrenergic neuron progenitors in Xenopus embryos.
- Source :
-
Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2008 Aug; Vol. 237 (8), pp. 2147-57. - Publication Year :
- 2008
-
Abstract
- The evolutionarily conserved IA1 (Insm1) gene is strongly expressed in the developing nervous system. Here, we show that IA1 is expressed during Xenopus laevis embryogenesis in neural plate primary neurons as well as in a population of uncharacterized anteroventral cells that form in front of the cement gland and that we identified as noradrenergic neurons. We also show that the formation of those anteroventral cells is dependent on BMPs and inhibited by Notch and that it is regulated by the transcription factors Xash1, Phox2, and Hand2. Finally, we provide functional evidence suggesting that IA1 may also play a role in their formation. Together, our results reveal that IA1 constitutes a novel player downstream of Xash1 in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons.<br /> (Copyright (c) 2008 Wiley-Liss, Inc.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors metabolism
Bone Morphogenetic Proteins metabolism
Cell Differentiation physiology
Cloning, Molecular
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Female
Homeodomain Proteins metabolism
Nerve Tissue Proteins metabolism
Neurons physiology
Receptors, Notch metabolism
Stem Cells physiology
Transcription Factors metabolism
Xenopus Proteins metabolism
Xenopus laevis genetics
Gene Expression Regulation, Developmental
Nervous System embryology
Norepinephrine physiology
Transcription Factors genetics
Xenopus Proteins genetics
Xenopus laevis embryology
Zinc Fingers genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1058-8388
- Volume :
- 237
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Developmental dynamics : an official publication of the American Association of Anatomists
- Publication Type :
- Academic Journal
- Accession number :
- 18627098
- Full Text :
- https://doi.org/10.1002/dvdy.21621